The TRPM2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TRPM2. This antibody recognizes Human, and Mouse antigen. The TRPM2 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity